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dc.contributor.supervisor Metz, Gerlinde A. S.
dc.contributor.author Ambeskovic, Mirela
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2019-06-19T18:03:05Z
dc.date.available 2019-06-19T18:03:05Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10133/5410
dc.description.abstract Early life stress alters fetal brain development with lifetime consequences on individuals exposed and future generations. This thesis investigated the effects of ancestral stress on behaviour, brain aging, and disease incidence of the F1-F4 generation offspring. Two types of ancestral stress offspring were examined: transgenerational stress, where only great-great grandma was stressed and mutigenerational stress where four consecutive F0-F3 generations were stressed during pregnancy. Here were report three main findings: 1) ancestral stress induced sex-specific anxiety-like behaviour and brain plasticity through altered epigenetic regulation; 2) the effects of ancestral stress persisted across the lifespan, altered physical and mental health and increased risk of disease; and 3) social isolation stress altered stress and immune systems and contributed to sex-specific cognitive impairments. These findings contribute to the overall understanding of the perinatal origins of healthy brain aging and disease, and address the urgent need of recommendations to support healthy aging worldwide. en_US
dc.description.sponsorship Natural Sciences and Engineering Research Council (NSERC) PGS Canadian Institutes of Health Research (CIHR) en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science)
dc.subject Stress en_US
dc.subject Behviour en_US
dc.subject Brain aging en_US
dc.subject Disease en_US
dc.subject Epigenetics en_US
dc.subject Sex-specific effects en_US
dc.title Sex-Specific Effects of Ancestral Stress on Brain Health and Disease Across the Lifespan en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Ph.D en_US
dc.proquest.subject Neurosciences [0317] en_US
dc.proquest.subject Psychobiology [0349] en_US
dc.proquest.subject Behavioral psychology [0384] en_US
dc.proquestyes Yes en_US
dc.embargo No en_US


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