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dc.contributor.author Spanswick, Simon C.
dc.contributor.author Sutherland, Robert J.
dc.date.accessioned 2019-04-04T21:16:09Z
dc.date.available 2019-04-04T21:16:09Z
dc.date.issued 2010
dc.identifier.citation Spanswick, S. C., & Sutherland, R. J. (2010). Object/context-specific memory deficits associated with loss of hippocampal granule cells after adrenalectomy in rats. Learning and Memory, 17(5), 241-245. Retrieved from http://www.learnmem.org/cgi/doi/10.1101/lm.1746710. en_US
dc.identifier.uri https://hdl.handle.net/10133/5322
dc.description Sherpa Romeo green journal. Permission to archive published version. en_US
dc.description.abstract Chronic adrenalectomy (ADX) causes a gradual and selective loss of granule cells in the dentate gyrus (DG) of the rat.Here, we administered replacement corticosterone to rats beginning 10wk after ADX. We then tested them in three discrimination tasks based on object novelty, location, or object/context association. Only during testing of the object/context association did ADX rats demonstrate deficits. These findings add to a body of evidence that the hippocampus is necessary when contextual information is important.We also confirm that memory deficits after chronic adrenalectomy are not a result of loss of corticosterone per se. en_US
dc.language.iso en_US en_US
dc.publisher Cold Spring Harbor Laboratory Press en_US
dc.subject Hippocampal en_US
dc.subject Granule cells en_US
dc.subject Memory deficits en_US
dc.subject Object memory en_US
dc.subject ADX rats en_US
dc.subject Object/context mismatch en_US
dc.subject Context memories en_US
dc.subject.lcsh Adrenalectomy
dc.subject.lcsh Rats as laboratory animals
dc.subject.lcsh Corticosterone
dc.subject.lcsh Memory--Research
dc.subject.lcsh Hippocampus (Brain)--Research
dc.subject.lcsh Dentate gyrus--Research
dc.subject.lcsh Brain--Research
dc.title Object/context-specific memory deficits associated with loss of hippocampal granule cells after adrenalectomy in rats en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.description.peer-review Yes en_US
dc.publisher.institution University of Lethbridge en_US


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