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dc.contributor.author Spanswick, Simon C.
dc.contributor.author Lehmann, Hugo
dc.contributor.author Sutherland, Robert J.
dc.date.accessioned 2019-04-04T03:46:21Z
dc.date.available 2019-04-04T03:46:21Z
dc.date.issued 2011
dc.identifier.citation Spanswick, S. C., Lehmann, H., & Sutherland, R. J. (2011). A novel animal model of hippocampal cognitive deficits, slow neurodegeneration, and neuroregeneration. Journal of Biomedicine and Biotechnology, article 527201. doi:10.1155/2011/527201 en_US
dc.identifier.uri https://hdl.handle.net/10133/5321
dc.description Sherpa Romeo green journal. Open access article. Creative Commons Attribution License applies. en_US
dc.description.abstract Long-term adrenalectomy (ADX) results in an extensive and specific loss of dentate gyrus granule cells in the hippocampus of adult rats. This loss of granule cells extends over a period of weeks to months and ultimately results in cognitive deficits revealed in a number of tasks that depend on intact hippocampal function. The gradual nature of ADX-induced cell death and the ensuing deficits in cognition resemble in some important respects a variety of pathological conditions in humans. Here, we characterize behavioural and cellular processes, including adult neurogenesis, in the rat ADX model.We also provide experimental evidence for a neurogenic treatment strategy by which the lost hippocampal cells may be replaced, with the goal of functional recovery in mind. en_US
dc.language.iso en_US en_US
dc.publisher Hindawi Publishing en_US
dc.subject Hippocampal en_US
dc.subject Long-term adrenalectomy en_US
dc.subject Cognitive deficits en_US
dc.subject Neurodegeneration en_US
dc.subject Neuroregeneration en_US
dc.subject Animal model
dc.subject Granule cell loss
dc.subject.lcsh Animal models in research
dc.subject.lcsh Hippocampus (Brain)--Research
dc.subject.lcsh Cell death
dc.subject.lcsh Dentate gyrus--Research
dc.subject.lcsh Brain--Research
dc.subject.lcsh Adrenalectomy
dc.title A novel animal model of hippocampal cognitive deficits, slow neurodegeneration, and neuroregeneration en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.description.peer-review Yes en_US
dc.publisher.institution University of Calgary en_US
dc.publisher.institution Trent University en_US
dc.publisher.institution University of Lethbridge en_US


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