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dc.contributor.author Jafari, Zahra
dc.contributor.author Mehla, Jogender
dc.contributor.author Afrashteh, Navvab
dc.contributor.author Kolb, Bryan E.
dc.contributor.author Mohajerani, Majid H.
dc.date.accessioned 2018-11-28T04:54:44Z
dc.date.available 2018-11-28T04:54:44Z
dc.date.issued 2017
dc.identifier.citation Jafari, Z., Mehla, J., Afrashteh, N. Kolb, B. E., & Mohajerani, M. H. (2017). Corticosterone response to gestational stress and postpartum memory function in mice. PLoS ONE, 12(7), e0180306. https://doi.org/10.1371/journal.pone.0180306 en_US
dc.identifier.uri https://hdl.handle.net/10133/5251
dc.description Open access; distributed under the terms of the Creative Commons Attribution License en_US
dc.description.abstract Maternal stress is a common adversity during pregnancy. Gestational corticosterone alternations are thought to contribute to the etiology of postpartum behavioral disturbances. However, the impact of stress during pregnancy, in particular noise exposure, on gestational corticosterone fluctuations and spatial cognition in postpartum mice has not been fully understood yet. We hypothesized that noise exposure during pregnancy negatively affects gestational corticosterone levels and postpartum memory function in the dams similar to the physical stressors. Pregnant C57BL/6 mice were randomly assigned to either one of two stress conditions or a control condition. The noise stress (NS) was induced by presenting a loud intermittent 3000 Hz frequency on gestational days (GDs) 12, 14, and 16 for 24 hours, whereas the physical stress (PS) consisted of restraint and exposure to an elevated platform on GDs 12–16. Plasma corticosterone level was collected on GDs 11 and 17, and Morris water task (MWT) was carried out 30 days after parturition. Compared to the control group, the level of corticosterone in the stressed groups was significantly increased on GD17 relative to GD11. Significantly longer swim time and lower swim speed were observed in both stressed groups relative to the control group. Probe time was significantly shorter in the NS group than the other groups. The delta corticosterone level was significantly correlated with the swim time as well as the probe time in the three groups. Given the results, the adverse effects of gestational noise exposure on the hypothalamic pituitary-adrenal (HPA) axis activation and postpartum spatial learning and memory function were as large as/ or a bit stronger than the physical stresses. The findings suggest the significance of conservation against loud noise exposure in daily living, as well as need to further notice to the different aspects of gestational stress in mothers’ behavior like offspring. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.subject Gestational stress en_US
dc.subject Maternal stress en_US
dc.subject Gestational corticosterone en_US
dc.subject Corticosterone fluctuations en_US
dc.subject Gestational noise exposure en_US
dc.subject Spatial cognition en_US
dc.subject Postpartum memory en_US
dc.subject Pregnant mice
dc.subject.lcsh Corticosterone
dc.subject.lcsh Noise--Health aspects
dc.subject.lcsh Mice--Effects of noise on
dc.subject.lcsh Mice--Research
dc.title Corticosterone response to gestational stress and postpartum memory function in mice en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.description.peer-review Yes en_US
dc.publisher.institution University of Lethbridge en_US
dc.publisher.institution Iran University of Medical Science (IUMS) en_US


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