Show simple item record Ward, Isaac D. Zucchi, Fabiola C.R. Robbins, Jerrah C. Falkenberg, Erin A. Olson, David M. Benzies, Karen Metz, Gerlinde A. S. 2018-06-01T17:16:36Z 2018-06-01T17:16:36Z 2013
dc.identifier.citation Ward, I.D., Zucchi, F.C.R., Robbins, J.C., Falkenberg, E.A., Olson, D.M., Benzies, K., & Metz, G.A. (2013). Transgenerational programming of maternal behaviour by prenatal stress. BMC Pregnancy & Childbirth, 13(Suppl 1), 59. doi:10.1186/1471-2393--13-S1-S9 en_US
dc.description Sherpa Romeo green journal. Open access, distributed under the terms of the Creative Commons Attribution (CC-BY) License en_US
dc.description.abstract Peripartum events hold the potential to have dramatic effects in the programming of physiology and behaviour of offspring and possibly subsequent generations. Here we have characterized transgenerational changes in rat maternal behaviour as a function of gestational and prenatal stress. Pregnant dams of the parental generation were exposed to stress from days 12-18 (F0-S). Their daughters and grand-daughters were either stressed (F1-SS, F2-SSS) or non-stressed (F1-SN, F2-SNN). Maternal antepartum behaviours were analyzed at a time when pregnant dams usually show a high frequency of tail chasing behaviours. F1-SS, F2-SNN and F2-SSS groups showed a significant reduction in tail chasing behaviours when compared with controls. The effects of multigenerational stress (SSS) slightly exceeded those of transgenerational stress (SNN) and resulted in absence of tail chasing behaviour. These findings suggest that antepartum maternal behaviour in rats is programmed by transgenerational inheritance of stress responses. Thus, altered antepartum maternal behaviour may serve as an indicator of an activated stress response during gestation. en_US
dc.language.iso en_US en_US
dc.publisher BioMed Central en_US
dc.subject Prenatal stress en_US
dc.subject Maternal behaviour en_US
dc.subject Multigenerational stress en_US
dc.subject Transgenerational stress en_US
dc.subject Tail chasing behaviour en_US
dc.subject Rats en_US
dc.subject Stress response en_US
dc.subject Gestation en_US
dc.subject.lcsh Rats--Behavior
dc.subject.lcsh Rats--Pregnancy
dc.title Transgenerational programming of maternal behaviour by prenatal stress en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.description.peer-review Yes en_US
dc.publisher.institution University of Lethbridge en_US
dc.publisher.institution University of Alberta en_US
dc.publisher.institution University of Calgary en_US

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