Show simple item record

dc.contributor.supervisor McNaughton, Bruce L.
dc.contributor.author Dube, Sutherland Theresa Ann
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2017-03-02T22:05:16Z
dc.date.available 2017-03-02T22:05:16Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/10133/4789
dc.description.abstract The longitudinal (or septotemporal) axis of the rodent hippocampus is generally described as being functionally segregated. However, the division between septal and temporal areas is not clearly delineated, and current anatomic, genetic, and physiological data propose varying gradients and domains that in large part do not coincide. In an attempt to clarify these issues, we mapped the behaviourally induced activity of neurons throughout the longitudinal axis of CA1 using immediate early genes (IEGs), which enable large-scale analysis of neuronal activity at the cellular level with a high degree of spatial resolution. Interestingly, the IEG data were not consistent with any of the proposed anatomical schemas or with the available single neuron recording data. The data suggest an alternative classification of hippocampal modules, with a functional domain in septal CA1 and a functional gradient through intermediate and temporal CA1. We suggest delineation between these two subdivisions of CA1 could correspond to amygdalar input to CA1. Further experiments could provide information on whether this input provides a basis for functional segregation at the level of neural activity dependent IEG expression. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta : University of Lethbridge, Dept. of Neuroscience en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject blobs en_US
dc.subject CA1 en_US
dc.subject hippocampal longitudinal axis en_US
dc.subject Homer1a en_US
dc.subject immediate-early genes en_US
dc.subject intranuclear transcription foci en_US
dc.title Mapping behaviourally induced immediate-early gene expression along the septotemporal axis of CA1 en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Masters en_US
dc.proquest.subject 0317 en_US
dc.proquest.subject 0307 en_US
dc.proquestyes Yes en_US
dc.embargo No en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record