Browsing Wieden, Hans-Joachim by Title

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  • Friedt, Jenna; Leavens, Fern M. V.; Mercier, Evan; Wieden, Hans-Joachim; Wieden-Kothe, Ute (Oxford University PressArts and ScienceDepartment of Chemistry and BiochemistryMax Planck Institute for Biophysical ChemistryUniversity of Lethbridge, 2014)
    Pseudouridine synthases introduce the most common RNA modification and likely use the same catalytic mechanism. Besides a catalytic aspartate residue, the contributions of other residues for catalysis of pseudouridine ...
  • Coatham, Mackenzie L.; Brandon, Harland E.; Fischer, Jeffrey J.; Schummer, Tobias; Wieden, Hans-Joachim (Oxford University PressArts and ScienceDepartment of Chemistry and BiochemistryUniversity of AlbertaUniversity of Lethbridge, 2016)
    Using a combination of biochemical, structural probing and rapid kinetics techniques we reveal for the first time that the universally conserved translational GTPase (trGTPase) HflX binds to the E-site of the 70S ribosome ...
  • Tillault, Anne-Sophie; Fourmann, Jean-Baptiste; Loegler, Christine; Wieden, Han-Joachim; Wieden-Kothe, Ute; Charpentier, Bruno (Cold Spring Harbor Laboratory PressArts and ScienceDepartment of Chemistry and BiochemistryBipole de l'Université de LorraineUniversity of Lethbridge, 2015)
    In all organisms, several distinct stand-alone pseudouridine synthase (PUS) family enzymes are expressed to isomerizeuridine into pseudouridine (Ψ) by specific recognition of RNAs. In addition, Ψs are generated in Archaea ...
  • Gzyl, Katherine E.; Wieden, Hans-Joachim (Public Library of ScienceArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridge, 2017)
    Understanding the molecular mechanism of antibiotics that are currently in use is important for the development of new antimicrobials. The tetracyclines, discovered in the 1940s, are a well-establis ...