Show simple item record

dc.contributor.author Boyko, Alexander
dc.contributor.author Kathiria, Palak
dc.contributor.author Zemp, Franz J.
dc.contributor.author Yao, Youli
dc.contributor.author Pogribny, Igor
dc.contributor.author Kovalchuk, Igor
dc.date.accessioned 2016-11-02T18:09:36Z
dc.date.available 2016-11-02T18:09:36Z
dc.date.issued 2007
dc.identifier.citation Boyko, A., Kathiria, P., Zemp, F. J., Yao, Y., Pogribny, I., & Kovalchuk, I. (2007). Transgenerational changes in the genome stability and methylation in pathogen-infected plants (virus-induced plant genome instability). Nucleic Acids Research, 35(5). doi:10.1093/nar/gkm029. en_US
dc.identifier.uri https://hdl.handle.net/10133/4645
dc.description Sherpa Romeo green journal: open access en_US
dc.description.abstract Previously, we reported the generation of a virusinduced systemic signal that increased the somatic and meiotic recombination rates in tobacco mosaic virus (TMV)-infected tobacco plants. Here, we analyzed the progeny of plants that received the signal and found that these plants also have a higher frequency of rearrangements in the loci carrying the homology to LRR region of the gene of resistance to TMV (N-gene). Analysis of the stability of repetitive elements from Nicotiana tabacum loci and 5.8S ribosomal RNA loci did not show any changes. Further analysis of the changes in the progeny of infected plants revealed that they had substantially hypermethylated genomes. At the same time, loci-specific methylation analysis showed: (1) profound hypomethylation in several LRR-containing loci; (2) substantial hypermethylation of actin loci and (3) no change in methylation in the loci of repetitive elements from N. tabacum or 5.8S ribosomal RNA. Global genome hypermethylation of the progeny is believed to be part of a general protection mechanism against stress, whereas locus-specific hypomethylation is associated with a higher frequency of rearrangements. Increased recombination events combined with the specific methylation pattern induced by pathogen attack could be a sign of an adaptive response by plants en_US
dc.language.iso en_CA en_US
dc.publisher Oxford University Press en_US
dc.subject Infected plants en_US
dc.subject Transgenerational changes en_US
dc.subject Genome stability en_US
dc.subject Methylation en_US
dc.subject Hypermethylation en_US
dc.subject Progeny en_US
dc.title Transgenerational changes in the genome stability and methylation in pathogen-infected plants (virus-induced plant genome instability) en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US
dc.description.peer-review Yes en_US
dc.publisher.institution University of Lethbridge en_US
dc.publisher.institution National Center for Toxicological Research en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record