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dc.contributor.author Bilichak, Andriy
dc.contributor.author Ilnytskyy, Yaroslav
dc.contributor.author Hollunder, Jens
dc.contributor.author Kovalchuk, Igor
dc.date.accessioned 2016-10-27T02:43:48Z
dc.date.available 2016-10-27T02:43:48Z
dc.date.issued 2012
dc.identifier.citation Bilichak, A., Ilnystkyy, Y., Hollunder, J., & Kovalchuk, I. (2012). The progeny of Arabidopsis thaliana plants exposed to salt exhibit changes in DNA methylation, histone modifications and gene expression. PLoS ONE, 7(1), e30515. doi:10.1371/journal.pone.0030515 en_US
dc.identifier.uri https://hdl.handle.net/10133/4629
dc.description Sherpa Romeo green journal: open access en_US
dc.description.abstract Plants are able to acclimate to new growth conditions on a relatively short time-scale. Recently, we showed that the progeny of plants exposed to various abiotic stresses exhibited changes in genome stability, methylation patterns and stress tolerance. Here, we performed a more detailed analysis of methylation patterns in the progeny of Arabidopsis thaliana (Arabidopsis) plants exposed to 25 and 75 mM sodium chloride. We found that the majority of gene promoters exhibiting changes in methylation were hypermethylated, and this group was overrepresented by regulators of the chromatin structure. The analysis of DNA methylation at gene bodies showed that hypermethylation in the progeny of stressed plants was primarily due to changes in the 59 and 39 ends as well as in exons rather than introns. All but one hypermethylated gene tested had lower gene expression. The analysis of histone modifications in the promoters and coding sequences showed that hypermethylation and lower gene expression correlated with the enrichment of H3K9me2 and depletion of H3K9ac histones. Thus, our work demonstrated a high degree of correlation between changes in DNA methylation, histone modifications and gene expression in the progeny of salt-stressed plants. en_US
dc.language.iso en_CA en_US
dc.publisher Public Library of Science en_US
dc.subject DNA methylation en_US
dc.subject Histone modifications en_US
dc.subject Gene expression en_US
dc.subject Arabidopsis thaliana en_US
dc.subject Stressed plants en_US
dc.subject Stress tolerance en_US
dc.subject Progeny en_US
dc.subject Salt-stressed plants en_US
dc.title The progeny of Arabidopsis thaliana plants exposed to salt exhibit changes in DNA methylation, histone modifications and gene expression en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US
dc.description.peer-review Yes en_US
dc.publisher.institution University of Lethbridge en_US
dc.publisher.institution Ghent University en_US


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