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dc.contributor.supervisor Metz, Gerlinde A. S.
dc.contributor.author Kiss, Douglas A.
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2016-09-22T17:27:28Z
dc.date.available 2016-09-22T17:27:28Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/10133/4610
dc.description.abstract Metabolomics provides a method to study the dynamics of cellular function by adopting a systems biology approach to the analysis of small molecule metabolites found in various bio-fluids and tissue locations. Chapters one and two of this thesis explore the theory behind metabolomics and reviews representative studies applying NMR metabolomics to neuroscience. Chapter three presents the results from an experiment investigating the alterations of metabolic by-products found in urine caused by both cumulative and remote ancestral prenatal maternal stress. Chapter four explores the results of a similar experiment where the liver tissue from offspring of either cumulative or remote ancestral prenatal maternal stress were analysed. Chapter five is a general discussion and conclusion of the results from both experiments and explores how both sets of results indicate an alteration in the stress response of the offspring. en_US
dc.language.iso en_CA en_US
dc.publisher Lethbridge, Alta : University of Lethbridge, Dept. of Neuroscience en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject metabolism en_US
dc.subject NMR spectroscopy en_US
dc.subject anxiety en_US
dc.subject depression en_US
dc.subject biomarker en_US
dc.title 1H NMR metabolomics of stress en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Masters en_US
dc.proquestyes No en_US
dc.embargo No en_US


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