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dc.contributor.author Olson, David M.
dc.contributor.author Severson, Emily M.
dc.contributor.author Verstraeten, Barbara S. E.
dc.contributor.author Ng, Jane W. Y.
dc.contributor.author McCreary, J. Keiko
dc.contributor.author Metz, Gerlinde A. S.
dc.date.accessioned 2016-07-28T00:31:28Z
dc.date.available 2016-07-28T00:31:28Z
dc.date.issued 2015
dc.identifier.citation Olson, D. M., Severson, E. M., Verstraeten, B. S. E., Ng, J. W. Y., McCreary, J. K., & Metz, G. A. S. (2015). Allostatic load and preterm birth. International Journal of Molecular Sciences, 16, 29856-29874. doi:10.3390/ijms161226209 en_US
dc.identifier.uri https://hdl.handle.net/10133/4560
dc.description Open access en_US
dc.description.abstract Preterm birth is a universal health problem that is one of the largest unmet medical needs contributing to the global burden of disease. Adding to its complexity is that there are no means to predict who is at risk when pregnancy begins or when women will actually deliver. Until these problems are addressed, there will be no interventions to reduce the risk because those who should be treated will not be known. Considerable evidence now exists that chronic life, generational or accumulated stress is a risk factor for preterm delivery in animal models and in women. This wear and tear on the body and mind is called allostatic load. This review explores the evidence that chronic stress contributes to preterm birth and other adverse pregnancy outcomes in animal and human studies. It explores how allostatic load can be used to, firstly, model stress and preterm birth in animal models and, secondly, how it can be used to develop a predictive model to assess relative risk among women in early pregnancy. Once care providers know who is in the highest risk group, interventions can be developed and applied to mitigate their risk. en_US
dc.language.iso en_CA en_US
dc.publisher M D P I A G en_US
dc.subject Allostatic load en_US
dc.subject Allostasis en_US
dc.subject Chronic stress en_US
dc.subject Preterm birth en_US
dc.subject Inflammation en_US
dc.subject Two hits en_US
dc.subject Multiple hit hypothesis en_US
dc.subject Adverse pregnancy outcomes en_US
dc.title Allostatic load and preterm birth en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.description.peer-review Yes en_US
dc.publisher.institution University of Alberta en_US
dc.publisher.institution University of Lethbridge en_US


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