Kovalchuk, Olga

 

Recent Submissions

  • Kovalchuk, Anna; Ilnytskyy, Yaroslav; Rodriquez-Juarez, Rocio; Katz, Amanda; Sidransky, David; Kolb, Bryan; Kovalchuk, Olga (Impact JournalsArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeChampions OncologyUniversity of Calgary, 2017)
    A wide array of central nervous system complications, neurological deficits, and cognitive impairments occur and persist as a result of systemic cancer and cancer treatments. This condition is known as chemo brain and it ...
  • Wang, Bo; Li, Dongping; Sidler, Corinne; Rodriquez-Juarez, Rocio; Singh, Natasha; Heyns, Mieke; Ilnytskyy, Yaroslav; Bronson, Roderick T.; Kovalchuk, Olga (Impact JournalsArts and ScienceDepartment of Biological SciencesUniversity of LethbridgeQiqihar Medical UniversityThe Dana Farber/Harvard Comprehensive Cancer Center, 2015)
    Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide, and it has been linked to radiation exposure. As a well-defined oncogene, wild-type p53-induced phosphatase 1 (WIP1) plays ...
  • Kochan, David Z.; Kovalchuk, Olga (Impact JournalsArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2015)
    Breast cancer is already the most common malignancy affecting women worldwide, and evidence is mounting that breast cancer induced by circadian disruption (CD) is a warranted concern. Numerous studies have investigated ...
  • Luzhna, Lidiya; Lykkesfeldt, Anne E.; Kovalchuk, Olga (Impact JournalsArts and ScienceDepartment of Biological SciencesUniversity of LethbridgeDanish Cancer Society Research Center, 2015)
    Endocrine therapy agents (the selective estrogen receptor (ER) modulators such as tamoxifen or the selective ER down-regulators such as ICI 182,780) are key treatment regimens for hormone receptor-positive breast cancers. ...
  • Kovalchuk, Anna; Mychasiuk, Richelle; Muhammad, Arif; Hossain, Shakhawat; Ilnytskyy, Slava; Ghose, Abhijit; Kirby, Charles; Ghasroddashti3, Esmaeel; Kovalchuk, Olga; Kolb, Bryan (Impact JournalsArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeAlberta Health ServicesUniversity of CalgaryAlberta Epigenetics NetworkCanadian Institute for Advanced Research, 2016)
    Radiation therapy can not only produce effects on targeted organs, but can also influence shielded bystander organs, such as the brain in targeted liver irradiation. The brain is sensitive to radiation exposure, and ...
  • Krishnan, Preethi; Ghosh, Sunita; Graham, Kathryn; Mackey, John R.; Kovalchuk, Olga; Damaraju, Sambasivarao (Impact JournalsArts and ScienceDepartment of Biological SciencesUniversity of AlbertaAlberta Health ServicesUniversity of Lethbridge, 2016)
    Piwi-interacting RNAs (piRNAs), whose role in germline maintenance has been established, are now also being classified as post-transcriptional regulators of gene expression in somatic cells. PIWI proteins, central to piRNA ...
  • Lezhnina, Ksenia; Kovalchuk, Olga; Zhavoronkov, Alexander A.; Korzinkin, Mikhail B.; Zabolotneva, Anastasia A.; Shegay, Peter V.; Sokov, Dmitry G.; Gaifullin, Nurshat M.; Rusakov, Igor G.; Aliper, Alexander M.; Roumiantsev, Sergey A.; Alekseev, Boris Y.; Borisov, Nikolay M.; Buzdin, Anton A. (Impact JournalsArts and ScienceDepartment of Biological SciencesPathway PharmaceuticalsD. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and ImmunologyUniversity of LethbridgeCanada Cancer and Aging Research Laboratories Ltd.John Hopkins UniversityMoscow Institute of Physics and TechnologyShemyakn-Ovchinnikov Institute of Bioorganic ChemistryP.A. Herzen Moscow Oncological Research InstituteMoscow 1st Oncological HospitalLomonosov Moscow State UniversityRussian Medical Postgraduate AcademyA.I. Burnasyan Federal Medical Biophysical Center, 2014)
    We recently proposed a new bioinformatic algorithm called OncoFinder for quantifying the activation of intracellular signaling pathways. It was proved advantageous for minimizing errors of high-throughput gene expression ...
  • Singhal, Sandeep K.; Usmani, Nawaid; Michiels, Stefan; Metzger-Filho, Otto; Saini, Kamal S.; Kovalchuk, Olga; Parliament, Matthew (Impact JournalsArts and ScienceDepartment of Biological SciencesUniversity of AlbertaService de Biostatistique et d'EpidemiologieUniversité Paris-SudHarvard Medical SchoolQuantum Health Analytics SPRLUniversity of LethbridgeCanada Cancer and Aging Research Laboratories Ltd., 2016)
    Until recently, an elevated disease risk has been ascribed to a genetic predisposition, however, exciting progress over the past years has discovered alternate elements of inheritance that involve epigenetic regulation. ...
  • Krishnan, Preethi; Ghosh, Sunita; Wang, Bo; Heyns, Mieke; Graham, Kathryn; Mackey, John R.; Kovalchuk, Olga; Damaraju, Sambasivarao (Public Library of ScienceArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2016)
    One of the most abundant,yet least explored,classes of RNA is the small nucleolar RNAs (snoRNAs), which are well known for their involvement in post-transcriptional modifications of other RNAs. Although snoRNAs were only ...
  • Krishnan, Preethi; Ghosh, Sunita; Wang, Bo; Heyns, Mieke; Li, Dongping; Mackey, John R.; Kovalchuk, Olga; Damaraju, Sambasivarao (Nature Publishing GroupArts and ScienceDepartment of Biological SciencesUniversity of AlbertaCross Cancer InstituteUniversity of Lethbridge, 2016)
    Transfer RNAs (tRNAs, key molecules in protein synthesis) have not been investigated as potential prognostic markers in breast cancer (BC), despite early findings of their dysregulation and diagnostic potential. We aim ...
  • Krishnan, Preethi; Ghosh, Sunita; Wang, Bo; Li, Dongping; Narasimhan, Ashok; Berendt, Richard; Graham, Kathryn; Mackey, John R.; Kovalchuk, Olga; Damaraju, Sambasivarao (BioMed CentralArts and ScienceDepartment of Biological SciencesUniversity of AlbertaCross Cancer InstituteUniversity of Lethbridge, 2015)
    Background: Prognostication of Breast Cancer (BC) relies largely on traditional clinical factors and biomarkers such as hormone or growth factor receptors. Due to their suboptimal specificities, it is challenging to ...
  • Kovalchuk, Anna; Mychasiuk, Richelle; Muhammad, Arif; Hossain, Shakhawat; Ilnytskyy, Yaroslav; Ghose, Abhijit; Kirkby, Charles; Ghasroddashti, Esmaeel; Kolb, Bryan; Kovalchuk, Olga (Frontiers MediaArts and ScienceDepartment of NeuroscienceDepartment of Biological SciencesUniversity of LethbridgeAlberta Epigenetics NetworkUniversity of CalgaryAlberta Health ServicesCanadian Institute for Advanced Research, 2016)
    Irradiated cells can signal damage and distress to both close and distant neighbors that have not been directly exposed to the radiation (naïve bystanders). While studies have shown that such bystander effects occur in the ...
  • Zucchi, Fabiola C. R.; Yao, Youli; Ward, Isaac D.; Ilnytskyy, Yaroslav; Olson, David M.; Benzies, Karen; Kovalchuk, Igor; Kovalchuk, Olga; Metz, Gerlinde A. S. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceDepartment of Biological SciencesUniversity of LethbridgeUniversity of Mato Grosso StateUniversity of AlbertaUniversity of Calgary, 2013)
    The gestational state is a period of particular vulnerability to diseases that affect maternal and fetal health. Stress during gestation may represent a powerful influence on maternal mental health and offspring brain ...
  • Kovalchuk, Igor; Walz, Paul; Thomas, James E.; Kovalchuk, Olga (Public Library of ScienceArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2013)
    Bacterial infection has been linked to carcinogenesis, however, there is lack of knowledge of molecular mechanisms that associate infection with the development of cancer. We analyzed possible effects of the consumption ...
  • Zucchi, Fabiola C. R.; Yao, Youli; Ilnytskyy, Yaroslav; Robbins, Jerrah C.; Soltanpour, Nasrin; Kovalchuk, Igor; Kovalchuk, Olga; Metz, Gerlinde A. S. (Public Library of ScienceArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeUniversity of Mato Grosso State, 2014)
    Prenatal stress (PS) represents a critical variable affecting lifetime health trajectories, metabolic and vascular functions. Beneficial experiences may attenuate the effects of PS and its programming of health outcomes ...
  • Kovalchuk, Igor; Kovalchuk, Olga (M D P I A GArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2008)
    Rapid technological development is inevitably associated with many environmental problems which primarily include pollution of soil, water and air. In many cases, the presence of contamination is difficult to assess. It ...
  • Yao, Youli; Robinson, Alexandra M.; Zucchi, Fabiola C. R.; Robbins, Jerrah C.; Babenko, Olena M.; Kovalchuk, Olga; Kovalchuk, Igor; Olson, David M.; Metz, Gerlinde A. S. (BioMed CentralArts and ScienceDepartment of Biological SciencesUniversity of LethbridgeUniversity of Alberta, 2014)
    Abstract Background: Chronic stress is considered to be one of many causes of human preterm birth (PTB), but no direct evidence has yet been provided. Here we show in rats that stress across generations has downstream ...