Neuroscience: Recent submissions

  • Lehmann, Hugo; Sparks, Fraser T.; Spanswick, Simon C.; Hadikin, Crystal; McDonald, Robert J.; Sutherland, Robert J. (Cold Spring Harbor Laboratory PressArts and ScienceDepartment of NeuroscienceTrent UniversityUniversity of Lethbridge, 2009)
    We present evidence that certain learning parameters can make a memory, even a very recent one, become independent of the hippocampus. We confirm earlier findings that damage to the hippocampus causes severe retrograde ...
  • Spanswick, Simon C.; Sutherland, Robert J. (Cold Spring Harbor Laboratory PressArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2010)
    Chronic adrenalectomy (ADX) causes a gradual and selective loss of granule cells in the dentate gyrus (DG) of the rat.Here, we administered replacement corticosterone to rats beginning 10wk after ADX. We then tested them ...
  • Spanswick, Simon C.; Lehmann, Hugo; Sutherland, Robert J. (Hindawi PublishingArts and ScienceDepartment of NeuroscienceUniversity of CalgaryTrent UniversityUniversity of Lethbridge, 2011)
    Long-term adrenalectomy (ADX) results in an extensive and specific loss of dentate gyrus granule cells in the hippocampus of adult rats. This loss of granule cells extends over a period of weeks to months and ultimately ...
  • Kovalchuk, Anna; Ilnytskyy, Yaroslav; Rodriquez-Juarez, Rocio; Katz, Amanda; Sidransky, David; Kolb, Bryan; Kovalchuk, Olga (Impact JournalsArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeChampions OncologyUniversity of Calgary, 2017)
    A wide array of central nervous system complications, neurological deficits, and cognitive impairments occur and persist as a result of systemic cancer and cancer treatments. This condition is known as chemo brain and it ...
  • Kovalchuk, Anna; Mychasiuk, Richelle; Muhammad, Arif; Hossain, Shakhawat; Ilnytskyy, Slava; Ghose, Abhijit; Kirby, Charles; Ghasroddashti3, Esmaeel; Kovalchuk, Olga; Kolb, Bryan (Impact JournalsArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeAlberta Health ServicesUniversity of CalgaryAlberta Epigenetics NetworkCanadian Institute for Advanced Research, 2016)
    Radiation therapy can not only produce effects on targeted organs, but can also influence shielded bystander organs, such as the brain in targeted liver irradiation. The brain is sensitive to radiation exposure, and ...
  • Wang, Justin; Wu, Chiping; Peng, Jessie; Patel, Nisarg; Huang, Yayi; Gao, Xiaoxing; Aljarallah, Salman; Eubanks, James H.; McDonald, Robert J.; Zhang, Liang (Public Library of ScienceArts and ScienceDepartment of NeuroscienceToronto Western Research InstituteUniversity of TorontoUniversity of LethbridgeKing Saud University, 2015)
    Aging is associated with an increased risk of seizures/epilepsy. Stroke(ischemic or hemorrhagic) and cardiac arrest related brain injury are two major causative factors for seizure development in this patient population. ...
  • Burke, Candace J.; Kisko, Theresa M.; Swiftwolfe, Hilarie; Pellis, Sergio M.; Euston, David R. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgePhilipps-University of Marburg, 2017)
    Rat ultrasonic vocalizations have been suggested to be either a byproduct of physical movement or, in the case of 50-kHz calls, a means to communicate positive affect. Yet there are up to 14 distinct types of 50-kHz calls, ...
  • Jafari, Zahra; Mehla, Jogender; Afrashteh, Navvab; Kolb, Bryan E.; Mohajerani, Majid H. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeIran University of Medical Science (IUMS), 2017)
    Maternal stress is a common adversity during pregnancy. Gestational corticosterone alternations are thought to contribute to the etiology of postpartum behavioral disturbances. However, the impact of stress during pregnancy, ...
  • Hambrook, Dillon A.; Ilievski, Marko; Mosadeghzad, Mohamad; Tata, Matthew S. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2017)
    The process of resolving mixtures of several sounds into their separate individual streams is known as auditory scene analysis and it remains a challenging task for computational systems. It is well-known that animals use ...
  • Chalmers, Eric; Luczak, Artur; Gruber, Aaron J. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2016)
    The mammalian brain is thought to use a version of Model-based Reinforcement Learning (MBRL) to guide “goal-directed” behavior, wherein animals consider goals and make plans to acquire desired outcomes. However, conventional ...
  • Gidyk, Darryl C.; Deibel, Scott H.; Hong, Nancy S.; McDonald, Robert J. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2015)
    Sporadic Alzheimer’s disease (AD) is the most prevalent form of age-related dementia. As such, great effort has been put forth to investigate the etiology, progression, and underlying mechanisms of the disease. Countless ...
  • Wilber, Aaron A.; Clark, Benjamin J.; Demecha, Alexis J.; Mesina, Lilia; Vos, Jessica M.; McNaughton, Bruce L. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeUniversity of CaliforniaUniversity of New Mexico, 2014)
    A central feature of theories of spatial navigation involves the representation of spatial relationships between objects in complex environments. The parietal cortex has long been linked to the processing of spatial visual ...
  • Ivan, Victorita E.; Banks, Parker J.; Goodfellow, Kris; Gruber, Aaron J. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2018)
    The propensity of animals to shift choices immediately after unexpectedly poor reinforcement outcomes is a pervasive strategy across species and tasks. We report here on the memory supporting such lose-shift responding in ...
  • Netelenbos, Nicole; Gibb, Robbin L.; Li, Fangfang; Gonzalez, Claudia L. R. (Frontiers MediaArts and ScienceDepartment of NeuroscienceDepartment of PsychologyUniversity of Lethbridge, 2018)
    Executive function (EF) and language learning play a prominent role in early childhood development. Empirical research continues to point to a concurrent relation between these two faculties. What has been given little ...
  • Faraji, Jamshid; Soltanpour, Nabiollah; Ambeskovic, Mirela; Zucchi, Fabiola C. R.; Beaumier, Pierre; Kovalchuk, Igor; Metz, Gerlinde A. S. (Frontiers MediaArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeGolestan University of Medical Sciences (GUMS)Babol University of Medical SciencesUniversity of BrasiliaCanAlt Health Laboratories, 2017)
    In a continuously stressful environment, the effects of recurrent prenatal stress (PS) may accumulate across generations and alter stress vulnerability and resilience. Here, we report in female rats that a family history ...
  • Ponjavic-Conte, Karla D.; Hambrook, Dillon A.; Pavlovic, Sebastian; Tata, Matthew S. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2013)
  • Stone, Scott A.; Tata, Matthew S. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2017)
    Many salient visual events tend to coincide with auditory events, such as seeing and hearing a car pass by. Information from the visual and auditory senses can be used to create a stable percept of the stimulus. Having ...
  • Ponjavic-Conte, Karla D.; Hambrook, Dillon A.; Pavlovic, Sebastian; Tata, Matthew S. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2013)
    Auditory distraction is a failure to maintain focus on a stream of sounds. We investigated the neural correlates of distraction in a selective-listening pitch-discrimination task with high (competing speech) or low (white ...
  • Gruber, Aaron J.; McDonald, Robert J. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2012)
    Motivated behavior exhibits properties that change with experience and partially dissociate among a number of brain structures. Here, we review evidence from rodent experiments demonstrating that multiple brain systems ...
  • Ward, Isaac D.; Zucchi, Fabiola C.R.; Robbins, Jerrah C.; Falkenberg, Erin A.; Olson, David M.; Benzies, Karen; Metz, Gerlinde A. (BioMed CentralArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeUniversity of AlbertaUniversity of Calgary, 2013)
    Peripartum events hold the potential to have dramatic effects in the programming of physiology and behaviour of offspring and possibly subsequent generations. Here we have characterized transgenerational changes in ...