Browsing Neuroscience by Subject "Rats as laboratory animals"

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  • Molina, Leonardo A.; Skelin, Ivan; Gruber, Aaron J. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2014)
    Antagonists of N-methyl-D-aspartate receptors (NMDAR) have psychotomimetic effects in humans and are used to model schizophrenia in animals. We used high-density electrophysiological recordings to assess the effects of ...
  • Thome, Alexander; Marrone, Diano F.; Ellmore, Timothy M.; Chawla, Monica K.; Lipa, Peter; Ramirez-Amaya, Victor; Lisanby, Sarah H.; McNaughton, Bruce L.; Barnes, Carol A. (Society for NeuroscienceArts and ScienceDepartment of NeuroscienceEvelyn F. McKnight Brain InstituteUniversity of ArizonaWilfrid Laurier UniversityCity College of New YorkUniversidad Autónoma de QueretaroInstituto deI nvestigación Médica Mercedes y Martín FerreyraDuke UniversityUniversity of LethbridgeUniversity of California, 2017)
    Decades of research identify the hippocampal formation as central to memory storage and recall. Events are stored via distributed population codes, the parameters of which (e.g., sparsity and overlap) determine both storage ...
  • Wilber, Aaron A.; Clark, Benjamin J.; Forster, Tyler C.; Tatsuno, Masami; McNaughton, Bruce L. (Society for NeuroscienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2014)
    Navigation requires coordination of egocentric and allocentric spatial reference frames and may involve vectorial computations relative to landmarks. Creation of are presentation of target heading relative to landmarks ...
  • Schwindel, C. Daniela; Ali, Karim; McNaughton, Bruce L.; Tatsuno, Masami (Society for NeuroscienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2014)
    Characterization of synaptic connectivity is essential to understanding neural circuit dynamics. For extracellularly recorded spike trains, indirect evidence for connectivity can be inferred from short-latency peaks in the ...
  • Lehmann, Hugo; Sparks, Fraser T.; Spanswick, Simon C.; Hadikin, Crystal; McDonald, Robert J.; Sutherland, Robert J. (Cold Spring Harbor Laboratory PressArts and ScienceDepartment of NeuroscienceTrent UniversityUniversity of Lethbridge, 2009)
    We present evidence that certain learning parameters can make a memory, even a very recent one, become independent of the hippocampus. We confirm earlier findings that damage to the hippocampus causes severe retrograde ...
  • Holec, Victoria; Pirot, Heather L.; Euston, David R. (Frontiers Research FoundationsArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2014)
    The rat anterior cingulate cortex (ACC) mediates effort-based decision making when the task requires the physical effort of climbing a ramp. Normal rats will readily climb a barrier leading to high reward whereas rats ...
  • Spanswick, Simon C.; Sutherland, Robert J. (Cold Spring Harbor Laboratory PressArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2010)
    Chronic adrenalectomy (ADX) causes a gradual and selective loss of granule cells in the dentate gyrus (DG) of the rat.Here, we administered replacement corticosterone to rats beginning 10wk after ADX. We then tested them ...
  • Morris, Renee; Whishaw, Ian Q. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2016)
    Spinal cord injury and repair is a dynamic field of research. The development of reliable animal models of traumatic spinal cord injury has been invaluable in providing a wealth of information regarding the pathological ...
  • Schwindel, C. Daniela; Navratilova, Zaneta; Ali, Karim; Tatsuno, Masami; McNaughton, Bruce L. (Society for NeuroscienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeUniversity of CaliforniaNeuroelectronic Research Flanders, 2016)
    The hippocampus is thought to contribute to episodic memory by creating, storing, and reactivating patterns that are unique to each experience, including different experiences that happen at the same location. Hippocampus ...
  • Whishaw, Ian Q. (Produced at the University of Lethbridge, 1972)
    A film by Ian Q. Whishaw and based on research by Ian Q. Whishaw, Brian H. Bland and C. H. Vanderwolf. Photography by Landy L. Esau. Produced at the University of Lethbridge.
  • Sparks, Fraser T.; Lehmann, Hugo; Hernandez, Khadaryna; Sutherland, Robert J. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeTrent University, 2011)
    Damage to the hippocampus (HPC) using the excitotoxin N-methyl-D-aspartate (NMDA) can cause retrograde amnesia for contextual fear memory. This amnesia is typically attributed to loss of cells in the HPC. However, NMDA ...