Chemistry & Biochemistry

 

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Recent Submissions

  • Villarreal, Oscar D.; Chen, Liao Y.; Whetten, Robert L.; Demeler, Borries (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas at San AntonioUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1021/acs.jpcb.5b09864, 2015)
    Nanometer-sized gold particles (AuNPs) are of peculiar interest because their behaviors in an aqueous solution are sensitive to changes in environmental factors including the size and shape of the solute ions. In order to ...
  • Ballandras-Colas, Allison; Brown, Monica; Cook, Nicola J.; Dewdney, Tamaria G.; Demeler, Borries; Cherepanov, Peter; Lyumkis, Dmitry; Engelman, Alan N. (Nature PublishingArts and ScienceDepartment of Chemistry and BiochemistryHarvard Medical SchoolThe Salk Institute for Biological StudiesThe Francis Crick InstituteUniversity of Texas Health Science Center at San AntonioImperial College LondonUniversity of Lethbridgehttps://doi.org/10.1038/nature16955, 2016)
    Retroviral integrase catalyses the integration of viral DNA into host target DNA, which is an essential step in the life cycle of all retroviruses1. Previous structural characterization of integrase–viral DNA complexes, ...
  • Alvarez, Marcos M.; Chen, Jenny; Plascencia-Villa, German; Black, David M.; Griffiths, Wendell P.; Garzon, Ignacio L.; Jose-Yacaman, Miguel; Demeler, Borrie; Whetten, Robert L. (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of TexasThermoFisher ScientificUniversidad Nacional Autonoma de MexicoUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1021/acs.jpcb.6b04525, 2016)
    Experimental and theoretical evidence reveals the resilience and stability of the larger aqueous gold clusters protected with p-mercaptobenzoic acid ligands (pMBA) of composition Aun(pMBA)p or (n, p). The Au144(pMBA)60, ...
  • Rubio-Marrero, Eva N.; Vincelli, Gabriele; Jeffries, Cy M.; Shaikh, Tanvir R.; Pakos, Irene S.; Ranaivoson, Fanomezana M.; von Daake, Sventja; Demeler, Borries; De Jaco, Antonella; Perkins, Guy; Ellisman, Mark H.; Trewhella, Jill; Comoletti, Davide (ASBMB PublicationsArts and ScienceDepartment of Chemistry and BiochemistryRutgers UniversityUniversity of SydneyMasaryk UniversityUniversity of Texas Health Science Center at San AntonioSapienza University of RomeUniversity of California San DiegoUniversity of UtahUniversity of Lethbridgehttps://doi.org/10.1074/jbc.M115.705681, 2015)
    Contactin-associated protein-like 2 (CNTNAP2) encodes for CASPR2, a multidomain single transmembrane protein belonging to the neurexin superfamily that has been implicated in a broad range of human phenotypes including ...
  • Bhattacharya, Akash; Wang, Zhonghua; White, Tommy; Buffone, Cindy; Nguyen, Laura A.; Shepard, Caitlin N.; Kim, Baek; Demeler, Borries; Diaz-Griffero, Felipe; Ivanov, Dmitri N. (Nature PublishingArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science Center at San AntonioAlbert Einstein College of MedicineEmory School of MedicineKyunghee UniversityUniversity of Lethbridgehttps://doi.org/10.1038/srep31353, 2016)
    SAMHD1, a dNTP triphosphohydrolase, contributes to interferon signaling and restriction of retroviral replication. SAMHD1-mediated retroviral restriction is thought to result from the depletion of cellular dNTP pools, but ...
  • Wong, Sarah J.; Gearhart, Micah D.; Taylor, Alexander B.; Nanyes, David R.; Ha, Daniel J.; Robinson, Angela K.; Artigas, Jason A.; Lee, Oliver J.; Demeler, Borries; Hart, P. John; Bardwell, Vivian J.; Kim, Chongwoo A. (ElsevierArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science Center at San AntonioUniversity of MinnesotaMidwestern UniversitySouth Texas Veterans Health Care SystemUniversity of Lethbridgehttps://doi.org/10.1016/j.str.2016.07.011, 2016)
    KDM2B recruits H2A-ubiquitinating activity of a non-canonical Polycomb Repression Complex 1 (PRC1.1) to CpG islands, facilitating gene repres sion. We investigated the molecular basis of recruit ment using in vitro ...
  • Karabudak, Engin; Brookes, Emre; Lesnyak, Vladimir; Gaponik, Nikolai; Eychmuller, Alexander; Walter, Johannes; Segets, Doris; Peukert, Wolfgang; Wohlleben, Wendel; Demeler, Borries; Colfen, Helmut (WileyArts and ScienceDepartment of Chemistry and BiochemistryMax Planck Institute of Colloids and InterfacesIzmir Institute of TechnologyUniversity of Texas Health Science Center at San AntonioTU DresdenFriedrich-Alexander-Universitat Erlangen-Nurnberg (FAU)BASE SEUniversity of Lethbridgehttps://doi.org/10.1002/anie.201603844, 2016)
    We report an unsurpassed solution characterization technique based on analytical ultracentrifugation, which demonstrates exceptional potential for resolving particle sizes in solution with sub-nm resolution. We achieve ...
  • Smirnova, Ekaterina; Kwan, Jamie J.; Siu, Ryan; Gao, Xin; Zoidl, Georg; Demeler, Borries; Saridakis, Vivian; Donaldson, Logan W. (BioMed CentralArts and ScienceDepartment of Chemistry and BiochemistryYork UniversityKing Abdullah University of Science and TechnologyUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1186/s12964-016-0140-3, 2016)
    CASKIN2 is a homolog of CASKIN1, a scaffolding protein that participates in a signaling network with CASK (calcium/calmodulin-dependent serine kinase). Despite a high level of homology between CASKIN2 and CASKIN1, CASKIN2 ...
  • Walter, Johannes; Gorbet, Gary E.; Akdas, Tugce; Segets, Doris; Demeler, Borries; Peukert, Wolfgang (Royal Society of ChemistryArts and ScienceDepartment of Chemistry and BiochemistryFriedrich-Alexander-Universitat Erlangen-Nurnberg (FAU)University of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1039/C6AN02236G, 2017)
    Accurate knowledge of the size, density and composition of nanoparticles (NPs) is of major importance for their applications. In this work the hydrodynamic characterization of polydisperse core–shell NPs by means of ...
  • Lopez, Priscilla; Lara, Humberto H.; Mullins, Sean M.; Black, David M.; Ramsower, Heidi M.; Alvarez, Marcos M.; Williams, Tayler L.; Lopez-Lozano, Xochitl; Weissker, Hans-Christian; Garcia, A. Patricio; Garzon, Ignacio L.; Demeler, Borries; Lopez-Ribot, Jose Luis; Yacaman, Miguel J.; Whetten, Robert L. (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of TexasUniversity of Texas Health Science Center at San AntonioAix Marseille UniversityUniversidad Nacional Autonoma de MexicoUniversity of Lethbridgehttps://doi.org/10.1021/acsanm.8b00069, 2018)
    Here we report on the identification and applications of an aqueous 29-atom silver cluster stabilized with 12 lipoate ligands, i.e. Ag29(R-α–LA)12 or (29,12), wherein R-α–LA = R-α-lipoic acid, a natural dithiolate. Its ...
  • Wagner, Jonathan M.; Christensen, Devin E.; Bhattacharya, Akash; Dawidziak, Daria M.; Roganowicz, Marcin D.; Wan, Yueping; Pumroy, Ruth A.; Demeler, Borries; Ivanov, Dmitri N.; Ganser-Pornillos, Barbie K.; Sundquist, Wesley I.; Pornillos, Owen (American Society for MicrobiologyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of VirginiaUniversity of UtahUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1128/JVI.01563-17, 2018)
    Restriction factors are intrinsic cellular defense proteins that have evolved to block microbial infections. Retroviruses such as HIV-1 are restricted by TRIM5 proteins, which recognize the viral capsid shell that surrounds, ...
  • Naz, Nabila R.; Schnakenburg, Gregor; Kelemen, Zsolt; Gal, Dalma; Nyulaszi, Laszlo; Boere, Rene T.; Streubel, Rainer (Royal Society of ChemistryArts and ScienceDepartment of Chemistry and BiochemistryFriedrich-Wilhelms-Universitat BonnBudapest University of Technology and EconomicsUniversity of Lethbridgehttps://doi.org/10.1039/D0DT03915B, 2021)
    A phosphanido-type bridged bis(imidazolium) salt, readily prepared in two steps via reductive deselenization of a tricyclic 1,4-diphosphinine diselone, affords access to a novel anionic P-functional tricyclic bis(NHC) via ...
  • Naz, Nabila R.; Schnakenburg, Gregor; Mikehazi, Antal; Kelemen, Zsolt; Nyulaszi, Laszlo; Boere, Rene T.; Streubel, Rainer (Royal Society of ChemistryArts and ScienceDepartment of Chemistry and BiochemistryFriedrich-Wilhelms-Universitat BonnBudapest University of Technology and EconomicsUniversity of Lethbridgehttps://doi.org/10.1039/C9CC08468A, 2020)
    Synthesis of the first tricyclic bis(carbenes) with facially opposed imidazole-2-ylidenes and two linking phosphorus centres in different oxidation states is presented using a modular, high-yield synthetic route. The ...
  • Marszaukowski, Flavia; Wohnrath, Karen; Boere, Rene T. (International Union of Crystallography (IUCr)Arts and ScienceDepartment of Chemistry and BiochemistryUniversidade Estadual de Ponta GrossaUniversity of Lethbridgehttps://doi.org/10.1107/S2056989020001413, 2020)
    The crystal structures of 5-bromo-1,3-di-tert-butyl-2-[(tri­methyl­sil­yl)­oxy]benzene, C17H29BrOSi, (I), 1,3-di-tert-butyl-2-[(tri­methyl­sil­yl)­oxy]benzene, C17H30OSi, (II), and N-(2,6-diiso­propyl­phen­yl)-1,1,1-trim ...
  • Shotonwa, Ibukun O.; Boere, Rene T. (Atlanta Publishing HouseArts and ScienceDepartment of Chemistry and BiochemistryLagos State UniversityUniversity of Lethbridgehttps://doi.org/10.5155/eurjchem.11.1.6-14.1946, 2020)
    The crystals of bis(4-pyridyl)acetylene are orthorhombic and belong to the space group Fddd. Solid-state investigation using conventional and Hirshfeld analytical techniques revealed valuable data and structural diversities ...
  • Shotonwa, Ibukun O.; Boere, Rene T. (Atlanta Publishing HouseArts and ScienceDepartment of Chemistry and BiochemistryLagos State UniversityUniversity of Lethbridgehttps://doi.org/10.5155/eurjchem.12.2.179-186.2108, 2021)
    The crystals of an unprecedented 2,4,5-tri(N-methylpyridinium)-1,3-thiazole are monoclinic and belong to the space group P21/c as determined by single-crystal XRD. Crystal data for C21H21I13N4S5.98: monoclinic, a = ...
  • Abbott, Jamie A.; Meyer-Schuman, Rebecca; Lupo, Vicenzo; Feeley, Shawna; Mademan, Ines; Oprescu, Stephanie N.; Griffin, Laurie B.; Alberti, M. Antonia; Casasnovas, Carlos; Aharoni, Sharon; Basel-Vanagaite, Lina; Zuchner, Stephan; De Jonghe, Peter; Baets, Jonathan; Shy, Michael E.; Espinos, Carmen; Demeler, Borries; Antonellis, Anthony; Francklyn, Christopher (WileyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of VermontUniversity of Michigan Medical SchoolCentro de Investigacion Principe Felipe (CIPF)University of Iowa Hospitals and ClinicsCenter for Molecular NeurologyInstitute Born-BungeHospital Universitario de BellvitgeTel Aviv UniversitySchneider Children's Medical Center of IsraelRabin Medical CenterUniversity of Miami Miller School of MedicineAntwerp University HospitalUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1002/humu.23380, 2018)
    Histidyl-tRNA synthetase (HARS) ligates histidine to cognate tRNA molecules, which is required for protein translation. Mutations in HARS cause the dominant axonal peripheral neuropathy Charcot-Marie-Tooth disease type 2W ...
  • Kim, Haram; Brookes, Emre; Cao, Weiming; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryCornell UniversityUniversity of Texas Health Science Center at San AntonioUniversity of Texas at San AntonioUniversity of Lethbridgehttps://doi.org/10.1007/s00249-018-1309-z, 2018)
    Sedimentation velocity experiments performed in the analytical ultracentrifuge are modeled using finite-element solutions of the Lamm equation. During modeling, three fundamental parameters are optimized: the sedimentation ...
  • Sterritt, Oliver W.; Lang, Eric J. M.; Kessans, Sarah A.; Ryan, Timothy M.; Demeler, Borries; Jameson, Geoffrey B.; Parker, Emily J. (Portland PressArts and ScienceDepartment of Chemistry and BiochemistryUniversity of CanterburyUniversity of AucklandAustralian Synchrotron/ANSTOUniversity of LethbridgeMassey UniversityVictoria University of Wellingtonhttps://doi.org/10.1042/BSR20181605, 2018)
    In Pseudomonas aeruginosa ( Pae ), the shikimate pathway end product, chorismate, serves as the last common precursor for the biosynthesis of both primary aromatic metabolites, including phenylalanine, tyrosine and tryptophan, ...
  • Bansal, Akanksha; Karanth, N. Megha; Demeler, Borries; Schindelin, Hermann; Sarma, Siddhartha P. (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryIndian Institute of Science, BangaloreUniversity of Texas Health Science Center at San AntonioUniversity of WeurzburgUniversity of Lethbridgehttps://doi.org/10.1021/acs.biochem.9b00050, 2019)
    Conformational factors that predicate selectivity for valine or isoleucine binding to IlvN leading to the regulation of aceto hydroxy acid synthase I (AHAS I) of Escherichia coli have been determined for the first time ...

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