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dc.contributor.supervisor Sutherland, Robert J.
dc.contributor.author Gidyk, Darryl C.
dc.date.accessioned 2013-01-18T20:27:55Z
dc.date.available 2013-01-18T20:27:55Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/10133/3236
dc.description ix, 75 leaves : col. ill. ; 29 cm en_US
dc.description.abstract The present thesis examines the effects of transcranial direct current stimulation and forelimb rehabilitation on motor recovery after stroke in rats. Post-stroke motor outcomes were quantified using an innovative battery of behavioural tests and high resolution, in vivo electrophysiology was employed to examine coherence of neural activity between hemispheres. It was shown that rats that received brain stimulation concurrently with forelimb rehabilitation displayed functional recovery, whereas rats that received rehabilitation alone partially regained motor function, but the improvements were not due to restitution of original movement patterns. Results from electrophysiological recordings showed that rats that received brain stimulation and rehabilitation regained pre-stroke levels of interhemispheric coherence, but rats that received rehabilitation alone did not. The present thesis suggests that transcranial direct current stimulation may be a viable adjunct therapy to increase the efficacy of physical rehabilitation with regard to post-stroke motor outcomes. Interhemishperic coherence between homotopic neuronal populations may represent a biomarker of genuine motor recovery after stroke. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2011 en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Cerebrovascular disease -- Research en_US
dc.subject Cerebrovascular disease -- Rehabilitation en_US
dc.subject Brain stimulation -- Therapeutic use en_US
dc.subject Brain stimulation -- Research en_US
dc.subject Brain stimulation -- Animal models en_US
dc.subject Physical therapy -- Therapeutic use en_US
dc.subject Physical therapy -- Animal models en_US
dc.subject Neuroplasticity -- Research en_US
dc.subject Rats as laboratory animals en_US
dc.subject Dissertations, Academic en_US
dc.title Modulation of compensation and recovery in a rat model of motor cortex stroke : implications of transcranial direct current stimulation en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Masters


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