Browsing University Archives by Title

Sort by: Order: Results:

  • Radiation induced epigenetic dysregulation in rat mammary gland tissue / Dorothy A. McRae 
    McRae, Dorothy A.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010Arts and ScienceDepartment of Biological Sciences, 2010)
    Most breast cancer patients undergo radiation diagnostics and are also treated with radiotherapy. In addition to being an important treatment modality, ionizing radiation (IR) is a potent tumour-causing agent that has been ...
  • Radiation responses of chemoresistant adenocarcinoma cells : from molecular mechanisms to new reversal strategies 
    Luzhna, Lidiya; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2009Arts and ScienceDepartment of Biological Sciences, 2009)
    Breast cancer is a major cause of cancer-related death among women throughout the world. Treatment of breast cancer often fails due to the development of resistance to both chemo- and radiotherapy. The aim of this study ...
  • Radiation-induced deregulation of PiRNA pathway proteins : a possible molecular mechanism underlying transgenerational epigenomic instability 
    Merrifield, Matthew; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Science, c2011Arts and ScienceDepartment of Biological Sciences, 2011)
    PiRNAs and their Piwi family protein partners are part of a germline specific epigenetic regulatory mechanism essential for proper spermatogenesis, silencing of transposable elements, and maintaining germline genome ...
  • Radiation-induced epigenome deregulation in the male germline 
    Tamminga, Jan; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008Arts and ScienceBiological Sciences, 2008)
    Approximately 45% of men will develop cancer during their lifetime; some of which will be of reproductive age (Canadian Cancer Society, 2008). Current advances in treatment regimens such as radiotherapy have significantly ...
  • Radiographic analysis of canine vocal tract anatomy and its implications for human language origins 
    Plotsky, Kyle; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Psychology, c2013Arts and ScienceDepartment of Psychology, 2013)
    Radiographic images of the skull and vocal tract of adults from two canid species were analyzed for two studies addressing functional issues in animal communication and human language. Study 1 tested the hypothesis that ...
  • Rangewide and local barriers to gene flow in white-crowned sparrows (Zonotrichia leucophrys) 
    Welke, Catherine A.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : Universtiy of Lethbridge, Department of Biological SciencesArts and ScienceDepartment of Biological Sciences, 2019)
    Although white-crowned sparrows (Z. leucophrys) have been extensively researched for physiology and behaviour, surprisingly little recent work has been done to characterize the population genetic structure of this widespread ...
  • Ranking components of scientific software using spectral methods 
    Khan, Soma Farin (Lethbridge, Alta : University of Lethbridge, Dept. of Mathematics and Computer ScienceArts and ScienceDepartment of Mathematics and Computer Science, 2015)
    In this thesis we explore the centrality rankings of functions in call graphs of scientific software using spectral method. Dependency Structure Matrix (DSM) is used as a modeling tool to represent and examine pattern ...
  • Rapid kinetic studies of PhyA from Selenomonas ruminantium, and a simplified means of production of a phosphate biosensor 
    Smith, Dustin D.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta : University of Lethbridge, Dept. of Chemistry and BiochemistryArts and ScienceDepartment of Biological SciencesDepartment of Chemistry and Biochemistry, 2016)
    Myo-inositol polyphosphates (IPs) are ubiquitous in nature and involved in various cellular events. Dephosphorylation of IPs by protein tyrosine phosphatase-like polyphosphatases (PTPLPs) occurs via a complex pathway, and ...
  • A rapid method for approximating invariant manifolds of differential equations 
    Tang, Shouchun (Terry); University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2006Arts and ScienceDepartment of Chemistry and Biochemistry, 2006)
    The Intrinsic Low-Dimensional Manifold (ILDM) has been adopted as an approximation to the slow manifold representing the long-term evolution of a non-linear chemical system. The computation of the slow manifold simplifies ...
  • Rational design of reduced alphabet proteins 
    Dhalla, Davinder Kaur; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : Dept. of Chemistry and BiochemistryArts and ScienceDepartment of Chemistry and Biochemistry, 2022)
    Conventional protein design approaches generally utilize a design space limited to the standard 20 amino acid alphabet (AAA), restricting the incorporation of unnatural amino acids, and associated novel functions. Reducing ...
  • (Re)imagining history and subjectivity : (dis)incar-nations of racialised citizenship 
    Shields, Rachel (Lethbridge, Alta. : University of Lethbridge, Dept. of Sociology, c2012Arts and ScienceDepartment of Sociology, 2012)
    This thesis explores the ways in which modern history-writing practices reiterate race-based categories of citizenship. To investigate these practices across time, I have examined discourses produced by the United Farm ...
  • Re-awakening wonder : creativity in elementary mathematics 
    Waite, Leslie Anne (Lethbridge, Alta. : University of Lethbridge, Faculty of Education, c2013Education, 2013)
    This thesis begins with the premise that in order to be mathematical students must first discover and develop their creativity. Within the context of classroom-based action research, the following questions are examined: ...
  • Re-creating identities: postwar Dutch Reformed immigrants in southern Alberta 
    Schalk, Lisa L.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta : University of Lethbridge, Dept. of HistoryArts and ScienceDepartment of History, 2016)
    This thesis examines how postwar Dutch immigrants who came to southern Alberta re-created their self-understanding in light of their new situations. Oral history interviews which I conducted with nine of these postwar ...
  • A re-examination of the retrosplenial contribution to place navigation in the rat 
    Harker, Kenneth Troy; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2002Arts and ScienceDepartment of Neuroscience, 2002)
    Behavioural, electrophysiological, and anatomical evidence suggests that retrosplenial (RS) cortex (areas RSA and RSG) plays a role in spatial navigation. It has been recently suggested that it is damage to the underlying ...
  • Re-imagining narratives of intimate violence: PhotoVoice inquiries with queer non/monogamous communities in Lethbridge, Alberta 
    Walker, Jaisie; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Women and Gender StudiesArts and ScienceDepartment of Women and Gender Studies, 2020)
    Seven collaborators in this project used PhotoVoice, a visual participatory action methodology, to explore the complexity of violence as it is lived, represented, and (re)defined in the context of queer non/monogamous ...
  • Re-writing publishing: fanfiction and self-publication in urban fantasy 
    Bay, Jessica L. (Lethbridge, Alta. : University of Lethbridge, Dept. of English, c2014Arts and ScienceDepartment of English, 2014)
    Fanfiction is the practice of fans writing stories using the world and/or characters of an established work of fiction in order to rework this material. This thesis examines the relationship between fanfiction and digital ...
  • A reassessment of Gallienus' reign 
    Kendrick, Troy; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of History, c2014Arts and ScienceDepartment of History, 2014)
    This thesis examines and reassesses the reign of the Roman emperor Gallienus in the mid-third century CE. Specifically, this paper analyses Gallienus’ military and administrative policies, his conception of his emperorship, ...
  • Reclaiming Buddhist sites in modern India: pilgrimage and tourism in Sarnath and Bodhgaya 
    Gandhi, Rutika; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : Universtiy of Lethbridge, Department of Religious StudiesArts and ScienceDepartment of Religious Studies, 2018)
    The promotion of Buddhist pilgrimage sites by the Government of India and the Ministry of Tourism has accelerated since the launch of the Incredible India Campaign in 2002. This thesis focuses on two sites, Sarnath and ...
  • Recommending expert developers using usage and implementation expertise 
    Akter, Sharmin; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Mathematics and Computer ScienceArts and ScienceDepartment of Mathematics and Computer Science, 2021)
    Knowing the expert developers of a software development project has great significance in large-scale and geographically distributed projects. However, finding these expert developers can be challenging, which becomes more ...
  • Reconceptualizing brand authenticity and validating its scale 
    Akbar, Mohammad Muzahid; University of Lethbridge. Faculty of Management (Lethbridge, Alta. : University of Lethbridge, Faculty of ManagementManagement, 2016-06-13)
    Brand authenticity represents the integration of a brand’s perceived originality, honesty, quality, and admirability. In contemporary brand management, brand authenticity is considered to be a new customer consciousness, ...